Experimental gestational hypothyroidism evokes hypertension in adult offspring rats
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Experimental gestational hypothyroidism evokes hypertension in adult offspring rats
Gestational hypothyroidism is a prevalent disorder in pregnant women. We aimed to investigate the impact of experimental gestational hypothyroidism (EGH) on cardiovascular and autonomic nervous systems (ANS) in the offspring of rats. EGH was induced with methimazole (MMI) 0.02% in drinking water from day 9 of gestation until birth. Sixty day old offspring from MMI-treated dams (OMTD, n=13) or w...
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Introduction: Increased oxidative stress is involved in the pathology of cardiovascular disease. Transient congenital hypothyroidism (TCH) leads to a variety of heart disorders during adulthood. In this study, the effect of TCH on antioxidant and oxidant systems in the serum and left cardiac ventricle of adult male rats was investigated. Materials and Methods: TCH was induced by administrating ...
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ژورنال
عنوان ژورنال: Autonomic Neuroscience
سال: 2012
ISSN: 1566-0702
DOI: 10.1016/j.autneu.2012.07.004